What does it mean if my TIBC is high?
A high TIBC, UIBC, or transferrin usually indicates iron deficiency, but they are also increased in pregnancy and with the use of oral contraceptives. A low TIBC, UIBC, or transferrin may also occur if someone has malnutrition, inflammation, liver disease, or nephrotic syndrome.
What causes low TIBC?
Lower-than-normal TIBC may mean: Anemia due to red blood cells being destroyed too quickly (hemolytic anemia) Lower-than-normal level of protein in the blood (hypoproteinemia) Inflammation.
Why is Tibc high in iron deficiency?
In iron–deficient conditions, the relative transferrin content compared to iron content increases, and thus the TIBC values are high. The opposite happens in iron overloaded states of the body; the quantity of free transferrin in blood decreases, and consequently, TIBC values are low.
What does TIBC test for?
A total iron-binding capacity (TIBC) test measures the blood’s ability to attach itself to iron and transport it around the body. A transferrin test is similar. If you have iron deficiency (a lack of iron in your blood), your iron level will be low but your TIBC will be high.
What does Iron and TIBC mean?
The serum iron test measures the amount of iron in your blood. The total iron-binding capacity (TIBC) test looks at how well the iron moves through your body. Iron is an important mineral that your body needs to stay healthy. Your body uses iron to make hemoglobin.
What level should your iron be?
Normal levels are generally between 35.5 and 44.9 percent for adult women and 38.3 to 48.6 percent for adult men. These values may change depending on your age. Hemoglobin. Lower than normal hemoglobin levels indicate anemia.
Why TIBC is low in anemia of chronic disease?
The total iron-binding capacity (TIBC), an indirect measurement of transferrin, is low in anemia of chronic disease because there is ample iron, but it is not easily available. TIBC tends to be increased when iron stores are diminished and decreased when they are elevated.
What does it mean if iron saturation is low?
Low serum iron may result from many chronic diseases and inflammatory states. Determination of the serum iron alone is of limited utility in the evaluation of iron stores and iron deficiency. TIBC is often increased in iron-deficiency anemia, and transferrin saturation of 15% or less is typically found.
What happens when your iron saturation is low?
Without enough iron, your body can’t produce enough of a substance in red blood cells that enables them to carry oxygen (hemoglobin). As a result, iron deficiency anemia may leave you tired and short of breath.
What’s the difference between iron and ferritin?
Ferritin isn’t the same thing as iron in your body. Instead, ferritin is a protein that stores iron, releasing it when your body needs it. Ferritin usually lives in your body’s cells, with very little actually circulating in your blood.
Is ferritin the same as iron?
Ferritin is a blood protein that contains iron. A ferritin test helps your doctor understand how much iron your body stores. If a ferritin test reveals that your blood ferritin level is lower than normal, it indicates your body’s iron stores are low and you have iron deficiency.
What is the difference between TIBC and UIBC?
The TIBC is the total iron-binding capacity; it equals UIBC plus the serum iron measurement. Some laboratories measure UIBC, some measure TIBC, and some measure transferrin. UIBC measures the unsaturated binding capacity of transferrin.
What is normal iron level for female?
The normal serum iron level for women is 60 mcg/dL to 140 mcg/dL. Total iron-binding capacity is 250 mcg/dL to 450 mcg/dL.
What is a normal iron saturation level?
Iron: 60 to 170 micrograms per deciliter (mcg/dL), or 10.74 to 30.43 micromoles per liter (micromol/L) Total iron binding capacity (TIBC): 240 to 450 mcg/dL, or 42.96 to 80.55 micromol/L. Transferrin saturation: 20% to 50%
What is iron called on a blood test?
Serum iron test—measures the level of iron in the liquid portion of the blood. Transferrin test—directly measures the level of transferrin in the blood. Transferrin is the protein that transports iron around in the body. Under normal conditions, transferrin is typically one-third saturated with iron.