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FAQ: What is ttp?

How do you treat TTP?

Treatment options for TTP refractory to PEX

  • Corticosteroids. Corticosteroids are used in the acute management of acquired TTP, and should be started upfront together with PEX.
  • Twice-daily PEX.
  • Rituximab.
  • Splenectomy.
  • Cyclosporine.
  • Cyclophosphamide and vincristine.
  • Bortezomib.
  • N-acetylcysteine.

How is TTP diagnosed?

Diagnosis. Laboratory studies for suspected TTP include a CBC, platelet count, blood smears, coagulation studies, BUN creatinine, and serum bilirubin and lactate dehydrogenase. The exact etiology of TTP is unknown.

What causes acquired TTP?

Acquired TTP is caused when a person’s body mistakingly makes antibodies that block the activity of the ADAMTS13 enzyme. THe ADAMTS13 enzyme normally helps control the activity of certain blood clotting factors. Treatment includes plasma exchange and in some cases may also include corticosteroid therapy or rituximab.

What is TTP blood disorder?

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder in which platelet clumps form in small blood vessels. This leads to a low platelet count (thrombocytopenia).

How long can you live with TTP?

The most striking evidence for the impact of morbidities following recovery from TTP is decreased survival. Among the 77 patients who survived their initial episode of TTP (1995-2017), 16 (21%) have subsequently died, all before their expected age of death (median difference, 22 years; range 4-55 years).

Is TTP autoimmune?

This form or TTP is considered to be an autoimmune disease and is caused when patients develop an antibody against the ADAMTS13 protease leading to low levels of the protease.

How common is TTP?

Thrombotic Thrombocytopenic Purpura is a rare blood disorder that is considered a true medical emergency. TTP is diagnosed at a rate of 3-4in 1 million people per year. Potentially fatal complications can result from internal blood clotting, with damage to critical organs such as the brain and heart.

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What drugs can cause TTP?

Substances

  • Antibiotics, Antineoplastic.
  • Immunosuppressive Agents.
  • Muscle Relaxants, Central.
  • Platelet Aggregation Inhibitors.
  • Mitomycin.
  • Cyclosporine.
  • Clopidogrel.
  • Quinine. Ticlopidine.

Is TTP genetic?

Inherited TTP is very rare – it is estimated that only 5% of all cases of TTP are inherited TTP. More commonly, people aren’t born with faulty genes but instead develop TTP at some point later in their lives. This is called acquired TTP (aTTP) or immune-mediated TTP.

Can TTP go away?

Thrombotic thrombocytopenic purpura (TTP) can be fatal or cause lasting damage, such as brain damage or a stroke, if it’s not treated right away. In most cases, TTP occurs suddenly and lasts for days or weeks, but it can go on for months.

Is TTP painful?

Our data confirm that patients with TTP present with a wide range of symptoms, not immediately suspicious for TTP, such as abdominal pain, nausea and vomiting.

Can TTP cause strokes?

Ischaemic stroke has been reported as a consequence of TTP. However, strokes due to a large cerebral artery occlusion (LCAO) are rare in patients with TTP.

Is TTP chronic?

The chronic, recurrent form of TTP may result from a congenital deficiency of the enzyme. The ultralarge multimers are thought to induce the aggregation of platelets, causing platelet consumption. Occlusion of microvasculature by the platelets in the brain, kidney, and other organs leads to myriad symptoms.

Why are platelets low in TTP?

Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. This results in a low platelet count, low red blood cells due to their breakdown, and often kidney, heart, and brain dysfunction.

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What is Purpura a symptom of?

Purpura occurs when small blood vessels burst, causing blood to pool under the skin. This can create purple spots on the skin that range in size from small dots to large patches. Purpura spots are generally benign, but may indicate a more serious medical condition, such as a blood clotting disorder.

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